Metabolic Pathways of 2, 4-Dichloro-1-nitrobenzene in <i>Mucor javanicus</i>
نویسندگان
چکیده
منابع مشابه
1 - Fluoro - 2 , 5 - dimethoxy - 4 - nitrobenzene
1-Fluoro-2,5-dimethoxy-4-nitrobenzene was synthesized in 90% yield by the reaction of commercial 2-fluoro-1,4-dimethoxybenzene with nitric acid. The structure was confirmed by X-ray crystallography. The new title compound was characterized by 1H and 13C-NMR, elemental analysis, EI-MS and FT-IR.
متن کاملCharacterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene.
Glutathione S-transferase Mu 1 (GSTM1) has been regarded as one of the key enzymes involved in phase II reactions in the liver, because of its high expression level. In this study, we generated mice with disrupted glutathione S-transferase Mu 1 gene (Gstm1-null mice) by gene targeting, and characterized the phenotypes by cytosolic and in vivo studies. The resulting Gstm1-null mice appeared to b...
متن کامل2-Dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol
In the title compound, C(23)H(29)Cl(2)NO, the fluorene ring is essentially planar, with a maximum deviation from the mean plane of 0.041 (1) Å. The amine group adopts a pyramidal configuration, the sum of the bond angles being 336.2 (3)°. In the crystal, the mol-ecules are linked into dimers by inter-molecular O-H⋯N and C-H⋯O hydrogen bonds. Weak C-H⋯π and π-π [centroid-centroid distance = 3.75...
متن کاملMethemoglobinemia induced by 1,2-dichloro-4-nitrobenzene in mice with a disrupted glutathione S-transferase Mu 1 gene.
A specific substrate to Mu class glutathione S-transferase (GST), 1,2-dichloro-4-nitrobenzene (DCNB), was administered to mice with a disrupted GST Mu 1 gene (Gstm1-null mice) to investigate the in vivo role of murine Gstm1 in toxicological responses to DCNB. A single oral administration of DCNB at doses of 500 and 1000 mg/kg demonstrated a marked increase in blood methemoglobin (MetHB) in Gstm...
متن کاملThirteen-week oral toxicity study of 1,4-dichloro-2-nitrobenzene in rats and mice.
Subchronic toxicity of 1,4-dichloro-2-nitrobenzene (DCNB) was examined by feeding F344 rats and BDF mice of both sexes a diet containing 1,481, 2,222, 3,333, 5,000 or 7,500 ppm DCNB (w/w) for 13 wk. Oral administration of DCNB in feed to rats and mice retarded growth rates and induced subchronic toxicity affecting the liver, kidney, testes and blood. Liver and kidney were most responsive to DCN...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pesticide Science
سال: 1987
ISSN: 1348-589X,1349-0923
DOI: 10.1584/jpestics.12.617